Evolutionary inactivation of a sialidase in group B Streptococcus

Evolutionary inactivation of a sialidase in group B Streptococcus

Group B Streptococcus (GBS) is a leading cause of bacterial sepsis and meningitis in newborns. GBS possesses a protein with homology to the pneumococcal virulence factor, NanA, which has neuraminidase (sialidase) activity and promotes blood-brain barrier penetration. However, phylogenetic sequence and enzymatic analyses indicate the GBS NanA ortholog has lost sialidase function - and for this d...

Investigation of Betahemolytic Streptococcus Group B in Natural Vaginal Flora

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Streptococcal sialidase. II. Kinetic and immunological studies of sialidase produced by group K streptococcus.

Kinetic and immunological studies were carried out on the sialidase produced by strain 6646, group K streptococcus (K-sialidase). The K(m) values of K-sialidase were 0.9 mm for sialyllactose and 0.17 mm for bovine submaxillary mucin. The antibody against K-sialidase was produced in rabbits immunized with this enzyme. An assay procedure for determination of the anti-K-sialidase activity in terms...

Frequency and Drug Resistance of Group B Streptococcus in Pregnant Women in Markazi Province, Iran

Abstract Background and Objective: Group B streptococcus is one of the agents leading to infantile blood infection and meningitis as well as aggressive infections in pregnant women. The vast use of antibiotics in order to prevent from the diseases caused by this bacterium has led to some concerns about the emergence of drug resistance in Group B streptococcus. Thus, we aimed to investigate Grou...

The Prevalence of Group B Streptococcus Colonization in Iranian Pregnant Women and Its Subsequent Outcome